Regional differences in effects of APOE ε4 on cognitive impairment in non-demented subjects.

Journal article

BACKGROUND: The APOE ε4 allele is a risk factor for Alzheimer's disease (AD). APOE ε4 is common in non-demented subjects with cognitive impairment. In both healthy people and people with AD, its prevalence has a north-south gradient across Europe. In the present study, we investigated whether the relation between the APOE ε4 allele and cognitive impairment varied across Northern, Middle and Southern Europe. We also investigated whether a north-south gradient existed in subjects with subjecti...

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Authors: Norberg, J; Graff, C; Almkvist, O; Ewers, M; Frisoni, G

• Publication status: Published
• Journal: Dementia and geriatric cognitive disorders
• Volume: 32
• Issue: 2
• Pages: 135-142
• Publication date: 2011-01-01
• DOI: 10.1159/000330492
• EISSN: 1421-9824
• ISSN: 1420-8008
• Language: English
• Keywords: Dementia; Gene Frequency; Cognition Disorders; Topography, Medical; Apolipoproteins E; Cognition; Reference Values; Europe; Humans