Journal article
A systematic review and empirical analysis of the relation between dose and duration of drug action
- Abstract:
-
There is a log-linear relation between the dose and duration of action of drugs with single-compartment pharmacokinetics and direct, reversible mechanisms of action. However, it has been suggested that this relation does not extend to drugs whose metabolites are active or slowly eliminated, drugs with saturable kinetics, and drugs with hit-and-run effects. The purpose of this study is to test this hypothesis and to quantify the relationship by way of a systematic review coupled to an empirica...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Bibliographic Details
- Publisher:
- Sage Publications Publisher's website
- Journal:
- Journal of Clinical Pharmacology Journal website
- Volume:
- 50
- Issue:
- 1
- Pages:
- 17-26
- Publication date:
- 2010-01-01
- DOI:
- ISSN:
-
0091-2700
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:a74dc4f3-72dc-4d15-95dd-e59c39f3345a
- Local pid:
- ora:3347
- Deposit date:
- 2010-02-12
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Terms of use
- Copyright holder:
- American College of Clinical Pharmacology
- Copyright date:
- 2010
- Notes:
- The final, definitive version of this paper has been published in the Journal of Clinical Pharmacology. Citation: Hughes, D. A. & Aronson, J. K. (2010). 'A systematic review and empirical analysis of the relation between dose and duration of drug action', Journal of Clinical Pharmacology, 50(1), 17-26 by Sage Publications Ltd. All rights reserved. © 2010 the American College of Clinical Pharmacology. The full-text of this article is not currently available in ORA, but you may be able to access the article via the publisher copy link on this record page.
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