Journal article icon

Journal article

IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses.

Abstract:

Polymorphisms in the gene encoding the transcription factor IRF5 that lead to higher mRNA expression are associated with many autoimmune diseases. Here we show that IRF5 expression in macrophages was reversibly induced by inflammatory stimuli and contributed to the plasticity of macrophage polarization. High expression of IRF5 was characteristic of M1 macrophages, in which it directly activated transcription of the genes encoding interleukin 12 subunit p40 (IL-12p40), IL-12p35 and IL-23p19 an...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1038/ni.1990

Authors


Expand authors...
Journal:
Nature immunology
Volume:
12
Issue:
3
Pages:
231-238
Publication date:
2011-03-05
DOI:
EISSN:
1529-2916
ISSN:
1529-2908
URN:
uuid:a74c4579-c61c-4bdd-aa03-5f5fd1d51e6e
Source identifiers:
224718
Local pid:
pubs:224718

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP