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Maternal iron deficiency perturbs embryonic cardiovascular development in mice

Abstract:

Congenital heart disease (CHD) is the most common class of human birth defects, with a prevalence of 0.9% of births. However, two-thirds of cases have an unknown cause, and many of these are thought to be caused by in utero exposure to environmental teratogens. Here we identify a potential teratogen causing CHD in mice: maternal iron deficiency (ID). We show that maternal ID in mice causes severe cardiovascular defects in the offspring. These defects likely arise from increased retinoic acid ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-021-23660-5

Authors


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Name:
Novo Nordisk A/S
Grant:
cms
More from this funder
Name:
British Heart Foundation
Grant:
FS/17/55/33100
Publisher:
Springer Nature
Journal:
Nature Communications More from this journal
Volume:
12
Article number:
3447
Publication date:
2021-06-08
Acceptance date:
2021-05-07
DOI:
EISSN:
2041-1723
Language:
English
Keywords:
Pubs id:
1175053
Local pid:
pubs:1175053
Deposit date:
2021-05-08

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