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Journal article

Single-dose protection against Plasmodium berghei by a simian adenovirus vector using a human cytomegalovirus promoter containing intron A.

Abstract:

Human adenovirus serotype 5 (AdH5) vector vaccines elicit strong immune responses to the encoded antigen and have been used in various disease models. We designed AdH5 vectors expressing antigen under the control of a human cytomegalovirus (HCMV) immediate-early promoter containing its intron A sequence. The transcriptional levels of antigen and immune responses to antigen for vectors with the HCMV promoter with the intron A sequence (LP) were greater than those for AdH5 vectors using the HCM...

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Publication status:
Published

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Publisher copy:
10.1128/jvi.02568-07

Authors


Sridhar, S More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine
Draper, SJ More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
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Journal:
Journal of virology
Volume:
82
Issue:
8
Pages:
3822-3833
Publication date:
2008-04-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:a739ec7d-2247-422d-9e20-421d04f2e7ba
Source identifiers:
34121
Local pid:
pubs:34121

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