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Journal article

Periodontitis in RA-the citrullinated enolase connection.

Abstract:

Autoimmunity in rheumatoid arthritis (RA) is characterized by an antibody response to citrullinated proteins. Two of the risk factors for RA-HLA-DRB1 shared epitope alleles and smoking-are also associated with periodontitis, which is largely, but not exclusively, caused by Porphyromonas gingivalis infection. Furthermore, RA and periodontitis have a similar pathophysiology, characterized by destructive inflammation. The citrullination of proteins by P. gingivalis and the subsequent generation ...

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Publication status:
Published

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Publisher copy:
10.1038/nrrheum.2010.139

Authors


Lundberg, K More by this author
Yucel-Lindberg, T More by this author
Venables, PJ More by this author
Journal:
Nature reviews. Rheumatology
Volume:
6
Issue:
12
Pages:
727-730
Publication date:
2010-12-05
DOI:
EISSN:
1759-4804
ISSN:
1759-4790
URN:
uuid:a7301f40-e8fd-43fe-b042-260ee85a1ab9
Source identifiers:
244864
Local pid:
pubs:244864

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