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Regulation of MLL1 H3K4 methyltransferase activity by its core components.

Abstract:

Histone H3 Lys4 (H3K4) methylation is a prevalent mark associated with transcription activation. A common feature of several H3K4 methyltransferase complexes is the presence of three structural components (RbBP5, Ash2L and WDR5) and a catalytic subunit containing a SET domain. Here we report the first biochemical reconstitution of a functional four-component mixed-lineage leukemia protein-1 (MLL1) core complex. This reconstitution, combined with in vivo assays, allows direct analysis of the c...

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Publication status:
Published

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Publisher copy:
10.1038/nsmb1128

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Journal:
Nature structural and molecular biology More from this journal
Volume:
13
Issue:
8
Pages:
713-719
Publication date:
2006-08-01
DOI:
EISSN:
1545-9985
ISSN:
1545-9993
Language:
English
Keywords:
Pubs id:
pubs:331906
UUID:
uuid:a72f1d17-3378-45c0-b7dd-a8747075badb
Local pid:
pubs:331906
Source identifiers:
331906
Deposit date:
2012-12-19

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