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Three dimensional perfused cell culture for in vitro toxicity testing

Abstract:

This study describes the development of a novel method of three dimensional perfused cell culture for in vitro toxicity testing. Multiple parallel perfused microbioreactors (TissueFlexTM) were adopted to provide a well-controlled cell culture environment. Alginate and collagen type I, commonly used as hydrogel scaffolds to support cell culture, were tested as the scaffolding materials for this application. Alginate supports cell proliferation, but does not support cell attachmen...

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Institution:
University of Oxford
Oxford college:
St Cross College
Department:
Mathematical,Physical & Life Sciences Division - Engineering Science
Role:
Author

Contributors

Role:
Supervisor
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:a72b7015-cc57-4bb8-904a-a5a88e2194f1
Local pid:
ora:11790

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