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Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms.

Abstract:

In a previous study, we identified somatic mutations of SF3B1, a gene encoding a core component of RNA splicing machinery, in patients with myelodysplastic syndrome (MDS). Here, we define the clinical significance of these mutations in MDS and myelodysplastic/myeloproliferative neoplasms (MDS/MPN). The coding exons of SF3B1 were screened using massively parallel pyrosequencing in patients with MDS, MDS/MPN, or acute myeloid leukemia (AML) evolving from MDS. Somatic mutations of SF3B1 were fou...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Lab Sciences
Role:
Author
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Journal:
Blood
Volume:
118
Issue:
24
Pages:
6239-6246
Publication date:
2011-12-01
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
Source identifiers:
246262

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