Journal article icon

Journal article

Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms.

Abstract:

In a previous study, we identified somatic mutations of SF3B1, a gene encoding a core component of RNA splicing machinery, in patients with myelodysplastic syndrome (MDS). Here, we define the clinical significance of these mutations in MDS and myelodysplastic/myeloproliferative neoplasms (MDS/MPN). The coding exons of SF3B1 were screened using massively parallel pyrosequencing in patients with MDS, MDS/MPN, or acute myeloid leukemia (AML) evolving from MDS. Somatic mutations of SF3B1 were fou...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Malcovati, L More by this author
Papaemmanuil, E More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Clinical Lab Sciences, Biomedical Research Centre
Della Porta, MG More by this author
Expand authors...
Journal:
Blood
Volume:
118
Issue:
24
Pages:
6239-6246
Publication date:
2011-12-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:a72a3e2b-d21e-4a2a-9178-32cd67a44ef3
Source identifiers:
246262
Local pid:
pubs:246262

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP