Journal article icon

Journal article

Long-term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke.

Abstract:

Neural stem cells (NSCs) in the adult rat subventricular zone (SVZ) generate new striatal neurons during several months after ischemic stroke. Whether the microglial response associated with ischemic injury extends into SVZ and influences neuroblast production is unknown. Here, we demonstrate increased numbers of activated microglia in ipsilateral SVZ concomitant with neuroblast migration into the striatum at 2, 6, and 16 weeks, with maximum at 6 weeks, following 2 h middle cerebral artery oc...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1002/glia.20810

Authors


Heldmann, U More by this author
Gomes-Leal, W More by this author
Darsalia, V More by this author
Expand authors...
Journal:
Glia
Volume:
57
Issue:
8
Pages:
835-849
Publication date:
2009-06-05
DOI:
EISSN:
1098-1136
ISSN:
0894-1491
URN:
uuid:a724bfa6-05c2-4e23-912d-f4c6f6c84f5d
Source identifiers:
246560
Local pid:
pubs:246560

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP