Journal article icon

Journal article

HLA-B27 and disease pathogenesis: new structural and functional insights.

Abstract:

The human leukocyte antigen class I allele HLA-B27 is a major histocompatibility complex (MHC) antigen that is strongly associated with the spondyloarthritic group of human rheumatic diseases, the most common of which is ankylosing spondylitis. Although the mechanism underlying this disease association remains unknown, numerous theories have been proposed. Much more is known of the natural role of HLA-B27 in binding and presenting antigenic peptides to T cells. The 'arthritogenic peptide hypo...

Expand abstract

Actions


Access Document


Publisher copy:
10.1017/S1462399499001118

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, Experimental Medicine Division
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Journal:
Expert reviews in molecular medicine
Volume:
1999
Issue:
16
Pages:
1-10
Publication date:
1999-10-05
DOI:
EISSN:
1462-3994
URN:
uuid:a723f8d2-4e57-4681-afda-ba83628265f3
Source identifiers:
9748
Local pid:
pubs:9748
Language:
English

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP