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Journal article

HLA-B27 and disease pathogenesis: new structural and functional insights.

Abstract:

The human leukocyte antigen class I allele HLA-B27 is a major histocompatibility complex (MHC) antigen that is strongly associated with the spondyloarthritic group of human rheumatic diseases, the most common of which is ankylosing spondylitis. Although the mechanism underlying this disease association remains unknown, numerous theories have been proposed. Much more is known of the natural role of HLA-B27 in binding and presenting antigenic peptides to T cells. The 'arthritogenic peptide hypo...

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Publisher copy:
10.1017/S1462399499001118

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
Journal:
Expert reviews in molecular medicine
Volume:
1999
Issue:
16
Pages:
1-10
Publication date:
1999-10-01
DOI:
EISSN:
1462-3994
Source identifiers:
9748
Language:
English
Pubs id:
pubs:9748
UUID:
uuid:a723f8d2-4e57-4681-afda-ba83628265f3
Local pid:
pubs:9748
Deposit date:
2012-12-19

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