Journal article icon

Journal article

A therapeutic human IgG4 monoclonal antibody that depletes target cells in humans.

Abstract:

It is traditionally held that human IgG4 MoAbs should not deplete target cells in vivo, as this isotype is inactive in a number of in vitro assays that measure effector function. We have previously challenged this dogma, and the current study was designed to investigate the in vivo biological effects in humans of a MoAb of human IgG4 isotype. Nine patients with refractory rheumatoid arthritis (RA) fulfilling ARA criteria, and one with ankylosing spondylitis (AS) received a human IgG4 Campath-...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Isaacs, JD More by this author
Greenwood, JD More by this author
Hazleman, BL More by this author
Expand authors...
Journal:
Clinical and experimental immunology
Volume:
106
Issue:
3
Pages:
427-433
Publication date:
1996-12-05
DOI:
EISSN:
1365-2249
ISSN:
0009-9104
URN:
uuid:a72378a2-df57-4a7b-9881-ae0107ff9bcb
Source identifiers:
7035
Local pid:
pubs:7035

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP