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HIV: current opinion in escapology.

Abstract:

Much recent work strongly supports the hypothesis that CD8(+) T lymphocytes (CTLs) exert important immune control over HIV and so are a major selective force in its evolution. We analyse this host-pathogen interplay and focus on new data that describe the overall 'effectiveness' of CTL responses (strength, spread, specificity and 'stamina') and the mechanisms by which HIV may evade this suppressive activity. CTLs directed against HIV recognise very large numbers of distinct epitopes across th...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Biomedical Research Centre
Phillips, R More by this author
Journal:
Current opinion in microbiology
Volume:
5
Issue:
4
Pages:
408-413
Publication date:
2002-08-05
DOI:
EISSN:
1879-0364
ISSN:
1369-5274
URN:
uuid:a722e8ee-b2e0-4315-9559-a5df17b398b8
Source identifiers:
21318
Local pid:
pubs:21318

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