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Progression of carcinogen-induced fibrosarcomas is associated with the accumulation of naïve CD4+ T cells via blood vessels and lymphatics

Abstract:

The tumor microenvironment comprises newly formed blood and lymphatic vessels which shape the influx, retention and departure of lymphocytes within the tumor mass. Thus, by influencing the intratumoral composition of lymphocytes, these vessels affect the manner in which the adaptive immune system responds to the tumor, either promoting or impairing effective antitumor immunity. In our study, we utilized a mouse model of carcinogen-induced fibrosarcoma to examine the composition of tumor-infil...

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Publisher copy:
10.1002/ijc.28556

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Journal:
International Journal of Cancer More from this journal
Volume:
134
Issue:
9
Pages:
2156-2167
Publication date:
2013-01-01
DOI:
EISSN:
1097-0215
ISSN:
0020-7136
Pubs id:
pubs:435251
UUID:
uuid:a7214c9d-10c0-40fc-8391-dac7ec33b62f
Local pid:
pubs:435251
Source identifiers:
435251
Deposit date:
2013-12-12

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