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Evidence for the role of megalin in renal uptake of transthyretin.

Abstract:

The kidney is a major organ for uptake of the thyroid hormone thyroxine (T(4)) and its conversion to the active form, triiodothyronine. In the plasma, one of the T(4) carriers is transthyretin (TTR). In the present study we observed that TTR, the transporter of both T(4) and retinol-binding protein, binds to megalin, the multiligand receptor expressed on the luminal surface of various epithelia including the renal proximal tubules. In the kidney, megalin plays an important role in tubular upt...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m002886200

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Journal:
Journal of biological chemistry More from this journal
Volume:
275
Issue:
49
Pages:
38176-38181
Publication date:
2000-12-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258

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