- Abstract:
-
Excessive synchronization of neuronal activity at around 20 Hz is a common finding in the basal ganglia of patients with untreated Parkinson's disease (PD). Correlative evidence suggests, but does not prove, that this spontaneous activity may contribute to slowness of movement in this condition. Here we investigate whether externally imposed synchronization through direct stimulation of the region of the subthalamic nucleus at 20 Hz can slow motor performance in a simple unimanual tapping tas...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.expneurol.2007.01.027
-
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- Journal:
- Experimental neurology
- Volume:
- 205
- Issue:
- 1
- Pages:
- 214-221
- Publication date:
- 2007-05-05
- DOI:
- EISSN:
-
1090-2430
- ISSN:
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0014-4886
- URN:
-
uuid:a71d601b-b915-4314-b2bc-6c487c38b925
- Source identifiers:
-
368912
- Local pid:
- pubs:368912
- Language:
- English
- Keywords:
- Copyright date:
- 2007
Journal article
Excessive synchronization of basal ganglia neurons at 20 Hz slows movement in Parkinson's disease.
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