Comparison of the immunogenicity and protection against bovine tuberculosis following immunization by BCG-priming and boosting with adenovirus or protein based vaccines.

Journal article

There is a requirement for vaccines or vaccination strategies that confer better protection against TB than the current live attenuated Mycobacterium bovis Bacillus Calmette-Guerin (BCG) vaccine for use in cattle. Boosting with recombinant viral vectors expressing mycobacterial proteins, such as Ag85A, has shown a degree of promise as a strategy for improving on the protection afforded by BCG. Experiments in small animal models have indicated that broadening the immune response to include myc...

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Authors: Dean, G; Whelan, A; Clifford, D; Salguero, F; Xing, Z

• Publication status: Published
• Journal: Vaccine
• Volume: 32
• Issue: 11
• Pages: 1304-1310
• Publication date: 2014-03-01
• DOI: 10.1016/j.vaccine.2013.11.045
• EISSN: 1873-2518
• ISSN: 0264-410X
• Language: English
• Keywords: Adenoviridae; Bacterial Load; Antigens, Bacterial; Tuberculosis, Bovine; Respiratory System; Interferon-gamma; Cattle; Immunization, Secondary; Animals; Cytokines; BCG Vaccine; T-Lymphocytes