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Palindromic sequence plays a critical role in human foamy virus dimerization.

Abstract:

The retroviral RNA genome is dimeric, consisting of two identical strands of RNA linked near their 5' ends by a dimer linkage structure. Previously it was shown that human foamy virus (HFV) RNA transcribed in vitro contained three sites, designated SI, SII, and SIII, which contributed to the dimerization process (O. Erlwein, D. Cain, N. Fischer, A. Rethwilm, and M. O. McClure, Virology 229:251-258, 1997). To characterize these sites further, a series of mutants were designed and tested for th...

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Journal of virology
Volume:
75
Issue:
8
Pages:
3731-3739
Publication date:
2001-04-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:a70fd0d1-e42e-43fd-ab80-0e86d8966ce8
Source identifiers:
237019
Local pid:
pubs:237019

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