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Diphenylacetylene-linked peptide strands induce bidirectional β-sheet formation.

Abstract:
In the search for synthetic mimics of protein secondary structures relevant to the mediation of protein-protein interactions, we have synthesized a series of tetrasubstituted diphenylacetylenes that display β-sheet structures in two directions. Extensive X-ray crystallographic and NMR solution phase studies are consistent with these proteomimetics adopting sheet structures, displaying both hydrophobic and hydrophilic amino acid side chains.
Publication status:
Published

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Publisher copy:
10.1002/anie.201309353

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Inorganic Chemistry
Role:
Author
Publisher:
Wiley
Journal:
Angewandte Chemie (International ed. in English) More from this journal
Volume:
53
Issue:
14
Pages:
3650-3653
Publication date:
2014-04-01
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
Language:
English
Keywords:
Pubs id:
pubs:449200
UUID:
uuid:a70df071-0881-440f-b8d5-519faac07a72
Local pid:
pubs:449200
Source identifiers:
449200
Deposit date:
2014-05-09

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