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Genes encoding the Ti beta subunit of the antigen/MHC receptor undergo rearrangement during intrathymic ontogeny prior to surface T3-Ti expression.

Abstract:

To obtain further information about the ontogeny of the T-cell antigen/MHC receptor, a Ti beta subunit cDNA probe and heteroantisera specific for the Ti alpha and Ti beta subunits were utilized to characterize human T-lineage cells. Analysis of thymic tumors and normal thymocytes at both the DNA and protein levels demonstrates that Ti beta gene rearrangement is evident in stage II (T11+T6+T3-) and stage III (T11+T6-T3+), but not stage I (T11+T6-T3-) thymocytes. In contrast, surface expression...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Journal:
Cell
Volume:
39
Issue:
2 Pt 1
Pages:
261-266
Publication date:
1984-12-01
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
Source identifiers:
20879
Language:
English
Keywords:
Pubs id:
pubs:20879
UUID:
uuid:a701f415-3e47-4538-9f9c-c6629eacfa49
Local pid:
pubs:20879
Deposit date:
2012-12-19

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