Journal article
Genes encoding the Ti beta subunit of the antigen/MHC receptor undergo rearrangement during intrathymic ontogeny prior to surface T3-Ti expression.
- Abstract:
-
To obtain further information about the ontogeny of the T-cell antigen/MHC receptor, a Ti beta subunit cDNA probe and heteroantisera specific for the Ti alpha and Ti beta subunits were utilized to characterize human T-lineage cells. Analysis of thymic tumors and normal thymocytes at both the DNA and protein levels demonstrates that Ti beta gene rearrangement is evident in stage II (T11+T6+T3-) and stage III (T11+T6-T3+), but not stage I (T11+T6-T3-) thymocytes. In contrast, surface expression...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/0092-8674(84)90003-5
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Bibliographic Details
- Journal:
- Cell
- Volume:
- 39
- Issue:
- 2 Pt 1
- Pages:
- 261-266
- Publication date:
- 1984-12-01
- DOI:
- EISSN:
-
1097-4172
- ISSN:
-
0092-8674
- Source identifiers:
-
20879
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:20879
- UUID:
-
uuid:a701f415-3e47-4538-9f9c-c6629eacfa49
- Local pid:
- pubs:20879
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 1984
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