- Abstract:
-
PURPOSE: To assess the expression of MMP (matrix metalloproteinase)-2 and -9 and TIMP (tissue inhibitors of metalloproteinases)-1, -2, and -3 in Sorsby fundus dystrophy. DESIGN: Cliniciopathological report. METHODS: A donor eye with a confirmed S181C mutation in the TIMP-3 gene and an age-matched normal donor eye were studied using in situ hybridization technique with MMP -2 and -9 and TIMP -1, -2, and -3 probes. RESULTS: There is a reduction of mRNA expression of MMP-2 and TIMP-3 in the Sor...
Expand abstract - Publisher copy:
- 10.1016/s0002-9394(03)00482-3
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- Journal:
- American journal of ophthalmology
- Volume:
- 136
- Issue:
- 5
- Pages:
- 954-955
- Publication date:
- 2003-11-05
- DOI:
- EISSN:
-
1879-1891
- ISSN:
-
0002-9394
- URN:
-
uuid:a6fd4810-114e-4f4f-8865-644df7ab26ce
- Source identifiers:
-
254178
- Local pid:
- pubs:254178
- Language:
- English
- Keywords:
- Copyright date:
- 2003
Journal article
TIMP-3 mRNA is not overexpressed in Sorsby fundus dystrophy.
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