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TIMP-3 mRNA is not overexpressed in Sorsby fundus dystrophy.

Abstract:

PURPOSE: To assess the expression of MMP (matrix metalloproteinase)-2 and -9 and TIMP (tissue inhibitors of metalloproteinases)-1, -2, and -3 in Sorsby fundus dystrophy. DESIGN: Cliniciopathological report. METHODS: A donor eye with a confirmed S181C mutation in the TIMP-3 gene and an age-matched normal donor eye were studied using in situ hybridization technique with MMP -2 and -9 and TIMP -1, -2, and -3 probes. RESULTS: There is a reduction of mRNA expression of MMP-2 and TIMP-3 in the Sor...

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Authors


Seregard, S More by this author
Luthert, PJ More by this author
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Journal:
American journal of ophthalmology
Volume:
136
Issue:
5
Pages:
954-955
Publication date:
2003-11-05
DOI:
EISSN:
1879-1891
ISSN:
0002-9394
URN:
uuid:a6fd4810-114e-4f4f-8865-644df7ab26ce
Source identifiers:
254178
Local pid:
pubs:254178

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