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Genetic studies of leptin concentrations implicate leptin in the regulation of early adiposity

Abstract:

Leptin influences food intake by informing the brain about the status of body fat stores. Rare LEP mutations associated with congenital leptin deficiency cause severe early-onset obesity that can be mitigated by administering leptin. However, the role of genetic regulation of leptin in polygenic obesity remains poorly understood. We performed an exome-based analysis in up to 57,232 individuals of diverse ancestries to identify genetic variants that influence adiposity-adjusted leptin concentr...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.2337/db20-0070

Authors


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Role:
Author
ORCID:
0000-0001-9763-8139
More from this funder
Name:
Novo Nordisk Foundation Center for Protein Research
Publisher:
American Diabetes Association
Journal:
Diabetes More from this journal
Volume:
69
Issue:
12
Pages:
2806-2818
Publication date:
2020-09-11
Acceptance date:
2020-09-09
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
Pmid:
32917775
Language:
English
Keywords:
Pubs id:
1132052
Local pid:
pubs:1132052
Deposit date:
2020-12-02

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