Journal article
Three-dimensional architecture of the human BRCA1-A histone deubiquitinase core complex
- Abstract:
-
BRCA1 is a tumor suppressor found to be mutated in hereditary breast and ovarian cancer and plays key roles in the maintenance of genomic stability by homologous recombination repair. It is recruited to damaged chromatin as a component of the BRCA1-A deubiquitinase, which cleaves K63-linked ubiquitin chains attached to histone H2A and H2AX. BRCA1-A contributes to checkpoint regulation, repair pathway choice, and HR repair efficiency through molecular mechanisms that remain largely obscure. Th...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
+ Wellcome Trust
More from this funder
Funding agency for:
Rosenthal, P
Smerdon, S
Grant:
FC001143
FC001143
104633/Z/14/Z
+ Medical Research Council
More from this funder
Funding agency for:
Rosenthal, P
Smerdon, S
Grant:
FC001143
FC001143
+ Cancer Research UK
More from this funder
Funding agency for:
Rosenthal, P
Smerdon, S
Grant:
FC001143
FC001143
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Cell Reports Journal website
- Volume:
- 17
- Issue:
- 12
- Pages:
- 3099–3106
- Publication date:
- 2016-12-22
- Acceptance date:
- 2016-11-21
- DOI:
- ISSN:
-
2211-1247
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:667804
- UUID:
-
uuid:a6f3622a-faf2-43b9-a57a-e21cd35de452
- Local pid:
- pubs:667804
- Source identifiers:
-
667804
- Deposit date:
- 2017-03-14
Terms of use
- Copyright holder:
- © 2016 Kyrieleis, et al
- Copyright date:
- 2016
- Notes:
- © 2016 Kyrieleis, et al. This is an Open Acess article published under a Creative Commons licence, see: https://creativecommons.org/licenses/by/4.0/
- Licence:
- CC Attribution (CC BY)
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