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Journal article

Three-dimensional architecture of the human BRCA1-A histone deubiquitinase core complex

Abstract:

BRCA1 is a tumor suppressor found to be mutated in hereditary breast and ovarian cancer and plays key roles in the maintenance of genomic stability by homologous recombination repair. It is recruited to damaged chromatin as a component of the BRCA1-A deubiquitinase, which cleaves K63-linked ubiquitin chains attached to histone H2A and H2AX. BRCA1-A contributes to checkpoint regulation, repair pathway choice, and HR repair efficiency through molecular mechanisms that remain largely obscure. Th...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
  • (Version of record, pdf, 3.8MB)
Publisher copy:
10.1016/j.celrep.2016.11.063

Authors


More from this funder
Name:
Wellcome Trust
Funding agency for:
Rosenthal, P
Smerdon, S
Grant:
FC001143
FC001143
104633/Z/14/Z
More from this funder
Name:
Medical Research Council
Funding agency for:
Rosenthal, P
Smerdon, S
Grant:
FC001143
FC001143
More from this funder
Name:
Cancer Research UK
Funding agency for:
Rosenthal, P
Smerdon, S
Grant:
FC001143
FC001143
Publisher:
Elsevier
Journal:
Cell Reports More from this journal
Volume:
17
Issue:
12
Pages:
3099–3106
Publication date:
2016-12-22
Acceptance date:
2016-11-21
DOI:
ISSN:
2211-1247
Language:
English
Keywords:
Pubs id:
pubs:667804
UUID:
uuid:a6f3622a-faf2-43b9-a57a-e21cd35de452
Local pid:
pubs:667804
Source identifiers:
667804
Deposit date:
2017-03-14

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