Cellular immunity induced by the recombinant Plasmodium falciparum malaria vaccine, RTS,S/AS02, in semi-immune adults in The Gambia.

Journal article

Vaccination of malaria-naive humans with recombinant RTS,S/AS02, which includes the C-terminus of the circumsporozoite protein (CS), has been shown to induce strong T cell responses to both the whole protein antigen and to peptides from CS. Here we show that strong T cell responses were also observed in a semi-immune population in The Gambia, West Africa. In a Phase I study, 20 adult male volunteers, lifelong residents in a malaria-endemic region, were given three doses of RTS,S/AS02 at 0, 1 ...

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Authors: Pinder, M; Reece, W; Plebanski, M; Akinwunmi, P; Flanagan, K

• Publication status: Published
• Journal: Clinical and experimental immunology
• Volume: 135
• Issue: 2
• Pages: 286-293
• Publication date: 2004-02-01
• DOI: 10.1111/j.1365-2249.2004.02371.x
• EISSN: 1365-2249
• ISSN: 0009-9104
• Language: English
• Keywords: Immunity, Cellular; Humans; Adolescent; T-Lymphocytes; Enzyme-Linked Immunosorbent Assay; Malaria, Falciparum; Malaria Vaccines; Cohort Studies; Hepatitis B Surface Antigens; Cells, Cultured; Middle Aged; Adult; Male; Vaccines, Synthetic; Interferon-gamma; Histocompatibility Testing; Cytotoxicity Tests, Immunologic; Antigens, Protozoan; Protozoan Proteins; Gambia; Lymphocyte Activation