Protease nexin 1 inhibits hedgehog signaling in prostate adenocarcinoma.

Journal article

Prostate adenocarcinoma (CaP) patients are classified into low-, intermediate-, and high-risk groups that reflect relative survival categories. While there are accepted treatment regimens for low- and high-risk patients, intermediate-risk patients pose a clinical dilemma, as treatment outcomes are highly variable for these individuals. A better understanding of the factors that regulate the progression of CaP is required to delineate risk. For example, aberrant activation of the Hedgehog (Hh)...

Expand abstract

Authors: McKee, C; Xu, D; Cao, Y; Kabraji, S; Allen, D

• Publication status: Published
• Journal: Journal of clinical investigation
• Volume: 122
• Issue: 11
• Pages: 4025-4036
• Publication date: 2012-11-01
• DOI: 10.1172/jci59348
• EISSN: 1558-8238
• ISSN: 0021-9738
• Language: English
• Keywords: Male; Transplantation, Heterologous; Humans; Neovascularization, Pathologic; Serpin E2; Hedgehog Proteins; Gene Expression Regulation, Neoplastic; Mice, Knockout; Prostatic Neoplasms; Neoplasm Proteins; Signal Transduction; Neoplasm Transplantation; Adenocarcinoma; Mice; Cell Line, Tumor; Animals