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Common genetic polymorphisms and haplotypes of fibrinogen alpha, beta, and gamma chains affect fibrinogen levels and the response to proinflammatory stimulation in myocardial infarction survivors: the AIRGENE study.

Abstract:

OBJECTIVES: This study was designed to investigate whether single nucleotide polymorphisms (SNPs) and haplotypes of the fibrinogen gene-cluster (fibrinogen chains alpha [FGA], beta [FGB], and gamma [FGG]) could explain the inter- and intraindividual variability of fibrinogen levels in patients with atherosclerosis. We also searched for genetic determinants affecting the responses of fibrinogen genes to proinflammatory stimulation. BACKGROUND: The mechanisms regulating fibrinogen levels are n...

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Publication status:
Published

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Publisher copy:
10.1016/j.jacc.2008.06.016

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Journal:
Journal of the American College of Cardiology
Volume:
52
Issue:
11
Pages:
941-952
Publication date:
2008-09-05
DOI:
EISSN:
1558-3597
ISSN:
0735-1097
URN:
uuid:a6ea5f3f-12e2-401d-94d8-f1eca9327df8
Source identifiers:
223265
Local pid:
pubs:223265

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