Administration of AS03B-adjuvanted A(H1N1)pdm09 vaccine in children aged <3 years enhances antibody response to H3 and B viruses following a single dose of trivalent vaccine one year later.

Journal article

BACKGROUND: We report on a follow-up clinical and serological investigation of 274 children who received seasonal influenza vaccine (trivalent inactivated vaccine [TIV]) 1 year after receipt of either AS03(B)-adjuvanted subunit or whole virus monovalent A(H1N1)pdm09 vaccine and describe the antibody responses to the H3N2 A/Perth/16/2009 and B/Brisbane/60/2008 components of TIV. METHODS: Vaccine responses were analyzed using hemagglutination inhibition (HAI) assays. In children aged <3 year...

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Authors: Hoschler, K; Andrews, N; Faust, SN; Finn, A; Pollard, A

• Publication status: Published
• Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
• Volume: 58
• Issue: 2
• Pages: 181-187
• Publication date: 2014-01-01
• DOI: 10.1093/cid/cit692
• EISSN: 1537-6591
• ISSN: 1058-4838
• Language: English
• Keywords: Cross Reactions; Humans; Antibodies, Viral; Polysorbates; Influenza Vaccines; Drug Combinations; Child; Adjuvants, Immunologic; Male; Hemagglutination Inhibition Tests; Infant; Influenza B virus; Influenza A Virus, H3N2 Subtype; Child, Preschool; Influenza A Virus, H1N1 Subtype; Follow-Up Studies; Squalene; Vaccination; Female; alpha-Tocopherol