Journal article
IκB Kinase α is required for development and progression of KRAS-mutant lung adenocarcinoma
- Abstract:
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Although oncogenic activation of NFkB has been identified in various tumors, the NFkB–activating kinases (inhibitor of NFkB kinases, IKK) responsible for this are elusive. In this study, we determined the role of IKKa and IKKb in KRAS-mutant lung adenocarcinomas induced by the carcinogen urethane and by respiratory epithelial expression of oncogenic KRASG12D. Using NFkB reporter mice and conditional deletions of IKKa and IKKb, we identified two distinct early and late activation phases of NFk...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Access Document
- Files:
-
-
(Accepted manuscript, pdf, 2.8MB)
-
- Publisher copy:
- 10.1158/0008-5472.can-17-1944
Authors
Bibliographic Details
- Publisher:
- American Association for Cancer Research Publisher's website
- Journal:
- Cancer Research Journal website
- Volume:
- 78
- Issue:
- 11
- Pages:
- 2939-2951
- Publication date:
- 2018-03-27
- Acceptance date:
- 2018-03-22
- DOI:
- EISSN:
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1538-7445
- ISSN:
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0008-5472
Item Description
- Language:
- English
- Pubs id:
-
pubs:859093
- UUID:
-
uuid:a6e58f0e-9440-410f-bd37-4d88a94c13a5
- Local pid:
- pubs:859093
- Source identifiers:
-
859093
- Deposit date:
- 2019-03-05
Terms of use
- Copyright holder:
- American Association for Cancer Research
- Copyright date:
- 2018
- Notes:
- © 2018 American Association for Cancer Research. This is the accepted manuscript version of the article. The final version of the paper can be found on the AACR at: https://doi.org/10.1158/0008-5472.can-17-1944
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