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IκB Kinase α is required for development and progression of KRAS-mutant lung adenocarcinoma

Abstract:

Although oncogenic activation of NFkB has been identified in various tumors, the NFkB–activating kinases (inhibitor of NFkB kinases, IKK) responsible for this are elusive. In this study, we determined the role of IKKa and IKKb in KRAS-mutant lung adenocarcinomas induced by the carcinogen urethane and by respiratory epithelial expression of oncogenic KRASG12D. Using NFkB reporter mice and conditional deletions of IKKa and IKKb, we identified two distinct early and late activation phases of NFk...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher:
American Association for Cancer Research
Journal:
Cancer Research More from this journal
Volume:
78
Issue:
11
Pages:
2939-2951
Publication date:
2018-03-27
Acceptance date:
2018-03-22
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
Language:
English
Pubs id:
pubs:859093
UUID:
uuid:a6e58f0e-9440-410f-bd37-4d88a94c13a5
Local pid:
pubs:859093
Source identifiers:
859093
Deposit date:
2019-03-05

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