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Meiotic prophase requires proteolysis of M phase regulators mediated by the meiosis-specific APC/CAma1.

Abstract:

Whereas proliferating cells enter M phase shortly after DNA replication, the first M phase of meiosis is preceded by an extended prophase in which homologous chromosomes undergo recombination. Exit from prophase I is controlled by the recombination checkpoint (RC), which, in yeast, represses the meiosis-specific transcription factor Ndt80 required for the expression of B-type cyclins and other M phase regulators. We show that an extended prophase I additionally requires the suppression of lat...

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Publication status:
Published

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Publisher copy:
10.1016/j.cell.2012.08.044

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Journal:
Cell
Volume:
151
Issue:
3
Pages:
603-618
Publication date:
2012-10-01
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
Source identifiers:
358324

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