- Abstract:
-
BACKGROUND: Epistatic interactions between human leukocyte antigen (HLA)-DRB1 alleles alter multiple sclerosis (MS) risk in Caucasians. Such interactions have never been studied in Asian MS patients. OBJECTIVE: To investigate the influence of HLA-DRB1 alleles, including epistatic interactions at this locus, in Japanese MS patients with and without the anti-aquaporin 4 (AQP4) antibody. METHODS: The HLA-DRB1 locus was genotyped in 108 MS patients and 127 healthy controls. MS patients were furt...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1177/1352458509355067
-
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- Journal:
- Multiple sclerosis (Houndmills, Basingstoke, England)
- Volume:
- 16
- Issue:
- 2
- Pages:
- 147-155
- Publication date:
- 2010-02-05
- DOI:
- EISSN:
-
1477-0970
- ISSN:
-
1352-4585
- URN:
-
uuid:a6e28156-191e-4599-a7ab-18074f1b7897
- Source identifiers:
-
48935
- Local pid:
- pubs:48935
- Language:
- English
- Keywords:
- Copyright date:
- 2010
Journal article
Influence of HLA-DRB1 alleles on the susceptibility and resistance to multiple sclerosis in Japanese patients with respect to anti-aquaporin 4 antibody status.
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