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Journal article

Influence of HLA-DRB1 alleles on the susceptibility and resistance to multiple sclerosis in Japanese patients with respect to anti-aquaporin 4 antibody status.

Abstract:

BACKGROUND: Epistatic interactions between human leukocyte antigen (HLA)-DRB1 alleles alter multiple sclerosis (MS) risk in Caucasians. Such interactions have never been studied in Asian MS patients. OBJECTIVE: To investigate the influence of HLA-DRB1 alleles, including epistatic interactions at this locus, in Japanese MS patients with and without the anti-aquaporin 4 (AQP4) antibody. METHODS: The HLA-DRB1 locus was genotyped in 108 MS patients and 127 healthy controls. MS patients were furt...

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Publication status:
Published

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Publisher copy:
10.1177/1352458509355067

Authors


Matsushita, T More by this author
Yamasaki, R More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
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Journal:
Multiple sclerosis (Houndmills, Basingstoke, England)
Volume:
16
Issue:
2
Pages:
147-155
Publication date:
2010-02-05
DOI:
EISSN:
1477-0970
ISSN:
1352-4585
URN:
uuid:a6e28156-191e-4599-a7ab-18074f1b7897
Source identifiers:
48935
Local pid:
pubs:48935

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