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Genetically predicted blood pressure across the lifespan: differential effects of mean and pulse pressure on stroke risk

Abstract:

Hypertension is the leading risk factor for stroke. Yet, it remains unknown whether blood pressure pulsatility (pulse pressure [PP]) causally affects stroke risk independently of the steady pressure component (mean arterial pressure [MAP]). It is further unknown how the effects of MAP and PP on stroke risk vary with age and stroke cause. Using data from UK Biobank (N=408 228; 38-71 years), we selected genetic variants as instruments for MAP and PP at age ≤55 and >55 years and across...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Sub department:
Clinical Neurosciences
Oxford college:
Wadham College
Role:
Author
ORCID:
0000-0002-0630-8204
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Name:
Wellcome Trust
Grant:
206589/Z/17/Z
Publisher:
American Heart Association
Journal:
Hypertension More from this journal
Volume:
76
Issue:
3
Pages:
953-961
Publication date:
2020-07-06
Acceptance date:
2020-06-03
DOI:
EISSN:
1524-4563
ISSN:
0194-911X
Pmid:
32623925

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