Journal article
Genetically predicted blood pressure across the lifespan: differential effects of mean and pulse pressure on stroke risk
- Abstract:
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Hypertension is the leading risk factor for stroke. Yet, it remains unknown whether blood pressure pulsatility (pulse pressure [PP]) causally affects stroke risk independently of the steady pressure component (mean arterial pressure [MAP]). It is further unknown how the effects of MAP and PP on stroke risk vary with age and stroke cause. Using data from UK Biobank (N=408 228; 38-71 years), we selected genetic variants as instruments for MAP and PP at age ≤55 and >55 years and across...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Version of record, 731.9KB)
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- Publisher copy:
- 10.1161/hypertensionaha.120.15136
Authors
Funding
Bibliographic Details
- Publisher:
- American Heart Association Publisher's website
- Journal:
- Hypertension Journal website
- Volume:
- 76
- Issue:
- 3
- Pages:
- 953-961
- Publication date:
- 2020-07-06
- Acceptance date:
- 2020-06-03
- DOI:
- EISSN:
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1524-4563
- ISSN:
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0194-911X
- Pmid:
-
32623925
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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1108857
- Local pid:
- pubs:1108857
- Deposit date:
- 2021-08-10
Terms of use
- Copyright holder:
- Georgakis et al.
- Copyright date:
- 2020
- Rights statement:
- © 2020 The Authors. Hypertension is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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