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Journal article

Macrophage migration inhibitory factor exhibits a pronounced circadian rhythm relevant to its role as a glucocorticoid counter-regulator.

Abstract:

In humans, maximal expression of T helper 1 cytokines coincide with the nocturnal nadir of plasma cortisol, whereas T helper 2 cytokine responses are dominant during day-time. The pro-inflammatory cytokine, macrophage migration inhibitory factor counter-regulates glucocorticoid-mediated immune suppression. To determine the relationship between cortisol and macrophage migration inhibitory factor, healthy volunteers had blood drawn hourly for 24 h for measurement of plasma cortisol and basal- a...

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Publication status:
Published

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Authors


Petrovsky, N More by this author
Grossman, AB More by this author
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Journal:
Immunology and cell biology
Volume:
81
Issue:
2
Pages:
137-143
Publication date:
2003-04-05
DOI:
EISSN:
1440-1711
ISSN:
0818-9641
URN:
uuid:a6d01355-439e-4c02-8abf-fd5ecb4e3608
Source identifiers:
138533
Local pid:
pubs:138533

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