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Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking.

Abstract:

Neuronal nicotinic acetylcholine receptor (nAChR) genes (CHRNA5/CHRNA3/CHRNB4) have been reproducibly associated with nicotine dependence, smoking behaviors, and lung cancer risk. Of the few reports that have focused on early smoking behaviors, association results have been mixed. This meta-analysis examines early smoking phenotypes and SNPs in the gene cluster to determine: (1) whether the most robust association signal in this region (rs16969968) for other smoking behaviors is also associat...

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Publication status:
Published

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Publisher copy:
10.1002/gepi.21760

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Journal:
Genetic epidemiology
Volume:
37
Issue:
8
Pages:
846-859
Publication date:
2013-12-01
DOI:
EISSN:
1098-2272
ISSN:
0741-0395
Source identifiers:
438893

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