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The BLT1 inhibitory function of α-1 antitrypsin augmentation therapy disrupts leukotriene B4 neutrophil signaling

Abstract:

Leukotriene B4 (LTB4) contributes to many inflammatory diseases, including genetic and nongenetic forms of chronic obstructive pulmonary disease. α-1 Antitrypsin (AAT) deficiency (AATD) is characterized by destruction of lung parenchyma and development of emphysema, caused by low AAT levels and a high neutrophil burden in the airways of affected individuals. In this study we assessed whether AATD is an LTB4-related disease and investigated the ability of serum AAT to control LTB4 signaling in...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.4049/jimmunol.1500038

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
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Name:
Health Research Board
Grant:
MRCG/2011/15
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Name:
Higher Education Authority, Ireland
Publisher:
American Association of Immunologists
Journal:
Journal of Immunology More from this journal
Volume:
195
Issue:
8
Pages:
3628-3641
Publication date:
2015-10-02
DOI:
ISSN:
1550-6606
Pubs id:
pubs:538164
UUID:
uuid:a6c3a4e1-f4aa-4c8a-b027-d44efc4ad044
Local pid:
pubs:538164
Source identifiers:
538164
Deposit date:
2015-08-13

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