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Journal article

Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time.

Abstract:

T cell receptor (TCR) binding to diverse peptide-major histocompatibility complex (pMHC) ligands results in various degrees of T cell activation. Here we analyze which binding properties of the TCR-pMHC interaction are responsible for this variation in pMHC activation potency. We have analyzed activation of the 1G4 cytotoxic T lymphocyte clone by cognate pMHC variants and performed thorough correlation analysis of T cell activation with 1G4 TCR-pMHC binding properties measured in solution. We...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Immunity More from this journal
Volume:
32
Issue:
2
Pages:
163-174
Publication date:
2010-02-01
DOI:
EISSN:
1097-4180
ISSN:
1074-7613
Language:
English
Keywords:
Pubs id:
pubs:48476
UUID:
uuid:a6bdff5a-8521-464f-ba33-e578c0408703
Local pid:
pubs:48476
Source identifiers:
48476
Deposit date:
2012-12-19

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