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Evidence for the mechanosensor function of filamin in tissue development

Abstract:

Cells integrate mechanical properties of their surroundings to form multicellular, three-dimensional tissues of appropriate size and spatial organisation. Actin cytoskeleton-linked proteins such as talin, vinculin and filamin function as mechanosensors in cells, but it has yet to be tested whether the mechanosensitivity is important for their function in intact tissues. Here we tested, how filamin mechanosensing contributes to oogenesis in Drosophila. Mutations that require more or l...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/srep32798

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Author
More from this funder
Name:
Cancer Research UK
Grant:
C6946/A14492
More from this funder
Name:
Wellcome Trust
Grant:
092096
More from this funder
Name:
Academy of Finland
Grant:
278668
Publisher:
Springer Nature
Journal:
Scientific Reports More from this journal
Volume:
6
Pages:
1-8
Publication date:
2016-09-06
Acceptance date:
2016-08-15
DOI:
EISSN:
2045-2322
ISSN:
2045-2322
Pmid:
27597179
Language:
English
Keywords:
Pubs id:
pubs:646245
UUID:
uuid:a6b9cf95-dc69-431f-9389-b62101d1c8eb
Local pid:
pubs:646245
Source identifiers:
646245
Deposit date:
2018-05-14

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