Proteolysis within the membrane: rhomboids revealed.

Journal article

The rhomboids are a recently discovered family of serine proteases with the unusual property of cleaving proteins within their transmembrane domains. They are the most widely conserved polytopic membrane proteins discovered so far. Although not much is known about the spectrum of their biological roles, it is already clear that rhomboids control events as diverse as growth factor signalling and mitochondrial membrane dynamics. As with other intramembrane proteases, the molecular details of ho...

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Authors: Freeman, M

• Publication status: Published
• Journal: Nature reviews. Molecular cell biology
• Volume: 5
• Issue: 3
• Pages: 188-197
• Publication date: 2004-03-01
• DOI: 10.1038/nrm1334
• EISSN: 1471-0080
• ISSN: 1471-0072
• Language: English
• Keywords: Membrane Proteins; Transcription Factors; Catalysis; Signal Transduction; Substrate Specificity; Golgi Apparatus; Amino Acid Motifs; CCAAT-Enhancer-Binding Proteins; DNA-Binding Proteins; Models, Biological; Gene Expression Regulation; Epidermal Growth Factor; Sterol Regulatory Element Binding Protein 1; Drosophila; Fungal Proteins; Animals; Drosophila Proteins; Protein Structure, Tertiary; Cell Membrane; Multigene Family