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Journal article

Oxygen-regulated and transactivating domains in endothelial PAS protein 1: comparison with hypoxia-inducible factor-1alpha.

Abstract:

Endothelial PAS protein 1 (EPAS1) is a basic helix-loop-helix Per-AHR-ARNT-Sim transcription factor related to hypoxia-inducible factor-1alpha (HIF-1alpha). To analyze EPAS1 domains responsible for transactivation and oxygen-regulated function, we constructed chimeric fusions of EPAS1 with a GAL4 DNA binding domain, plus or minus the VP16 activation domain. Two transactivation domains were defined in EPAS1; a C-terminal domain (amino acids 828-870), and a larger internal domain (amino acids 5...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.274.4.2060

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP, Biomedical Research Centre
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP, BHF Centre of Research Excellence
Role:
Author
Journal:
The Journal of biological chemistry
Volume:
274
Issue:
4
Pages:
2060-2071
Publication date:
1999-01-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:a6b1a97b-52c3-49df-a44d-3d5a31ed8892
Source identifiers:
7976
Local pid:
pubs:7976

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