Journal article
Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice
- Abstract:
-
Pharmacological targeting of transcription factors (TF) holds great promise for the development of new therapeutics, but strategies based on blockade of DNA binding, nuclear shuttling, or individual protein partner recruitment have yielded limited success. TFs typically engage in complex interaction networks, likely masking the effects of specifically inhibiting single protein-protein interactions. Here, we used a combination of genomic, proteomic and biophysical methods to discover a suite o...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Bibliographic Details
- Publisher:
- eLife Sciences Publications Publisher's website
- Journal:
- eLife Journal website
- Volume:
- 6
- Article number:
- e21221
- Publication date:
- 2017-01-01
- Acceptance date:
- 2016-12-07
- DOI:
- ISSN:
-
2050-084X
Item Description
- Keywords:
- Pubs id:
-
pubs:666082
- UUID:
-
uuid:a6b10b1a-0443-4a8b-b926-8632e59228c5
- Local pid:
- pubs:666082
- Source identifiers:
-
666082
- Deposit date:
- 2016-12-15
Terms of use
- Copyright holder:
- Overman et al
- Copyright date:
- 2017
- Notes:
-
Copyright © 2017 Overman et al.
This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record