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Meta-analyses involving cross-over trials: methodological issues.

Abstract:

BACKGROUND: Meta-analysis of randomized controlled trials (RCTs) is usually based on trials where patients are randomized individually into two different, parallel, treatment groups. This paper concentrates on RCTs of a different design-two-period, two-treatment cross-over trials. METHODS: The characteristics of these trials are outlined, with detailed examples of methods for analysis for both continuous and binary data. These case studies are then extended into the context of a meta-analysi...

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Publication status:
Published

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Publisher copy:
10.1093/ije/31.1.140

Authors


Elbourne, DR More by this author
Altman, DG More by this author
Higgins, JP More by this author
Worthington, HV More by this author
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Journal:
International journal of epidemiology
Volume:
31
Issue:
1
Pages:
140-149
Publication date:
2002-02-05
DOI:
EISSN:
1464-3685
ISSN:
0300-5771
URN:
uuid:a6afa929-eeea-42d4-a1de-f45296d52c03
Source identifiers:
317827
Local pid:
pubs:317827

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