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Reduction of aversive learning rates in Pavlovian conditioning by angiotensin II antagonist losartan: a randomized controlled trial

Abstract:

Background: Angiotensin receptor blockade has been linked to aspects of aversive learning and memory formation and to the prevention of posttraumatic stress disorder symptom development.

Methods: We investigated the influence of the angiotensin receptor blocker losartan on aversive Pavlovian conditioning using a probabilistic learning paradigm. In a double-blind, randomized, placebo-controlled design, we tested 45 (18 female) healthy volunteers dur...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.biopsych.2024.01.020

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
ORCID:
0000-0001-9108-3144
Publisher:
Elsevier
Journal:
Biological Psychiatry More from this journal
Volume:
96
Issue:
4
Pages:
247-255
Publication date:
2024-02-02
Acceptance date:
2024-01-22
DOI:
ISSN:
0006-3223
Language:
English
Keywords:
Pubs id:
1620344
Local pid:
pubs:1620344
Deposit date:
2024-02-19

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