Efferent loop small intestinal vitamin D receptor concentration and bone mineral density after Billroth II (Polya) gastrectomy in humans.

Journal article

Animal studies have demonstrated that the highest concentration of vitamin D receptors (and greatest capacity for active calcium absorption) occurs in the proximal duodenum. By passing the duodenum following Polya/Billroth II gastrectomy could result in the development of a metabolic bone disease and low bone mineral density (BMD). We thus compared the vitamin D receptor (VDR) concentration in mucosal biopsies taken at endoscopy from two functionally corresponding areas of the small intestine...

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Authors: Pazianas, M; Zaidi, M; Subhani, J; Finch, P; Ang, L

• Journal: Calcified tissue international
• Volume: 72
• Issue: 4
• Pages: 485-490
• Publication date: 2003-04-01
• DOI: 10.1007/s00223-001-2135-2
• EISSN: 1432-0827
• ISSN: 0171-967X
• Language: English
• Keywords: Receptors, Calcitriol; Jejunum; Postoperative Complications; Aged; Calcium; Bone and Bones; Aged, 80 and over; Gastroenterostomy; Aging; Female; Intestine, Small; Bone Density; Humans; Bone Diseases, Metabolic; Vitamin D; Down-Regulation; Duodenum; Middle Aged; Male