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Proline-induced distortions of transmembrane helices.

Abstract:

Proline residues in the transmembrane (TM) alpha-helices of integral membrane proteins have long been suspected to play a key role for helix packing and signal transduction by inducing regions of helix distortion and/or dynamic flexibility (hinges). In this study we try to characterise the effect of proline on the geometric properties of TM alpha-helices. We have examined 199 transmembrane alpha-helices from polytopic membrane proteins of known structure. After examining the location of proli...

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Publication status:
Published

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Journal:
Journal of molecular biology More from this journal
Volume:
323
Issue:
5
Pages:
951-960
Publication date:
2002-11-01
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
Language:
English
Keywords:
Pubs id:
pubs:100692
UUID:
uuid:a69a9785-1ecf-4c8a-8346-88c6d026b60a
Local pid:
pubs:100692
Source identifiers:
100692
Deposit date:
2012-12-19

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