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Galectin-3 modulates postnatal subventricular zone gliogenesis

Abstract:

Postnatal subventricular zone (SVZ) neural stem cells generate forebrain glia, namely astrocytes and oligodendrocytes. The cues necessary for this process are unclear, despite this phase of brain development being pivotal in forebrain gliogenesis. Galectin-3 (Gal-3) is increased in multiple brain pathologies and thereby regulates astrocyte proliferation and inflammation in injury. To study the function of Gal-3 in inflammation and gliogenesis, we carried out functional studies in mouse. We ov...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
ORCID:
0000-0001-9127-7061
More from this funder
Name:
Biotechnology and Biological Sciences Research Council
Funder identifier:
http://dx.doi.org/10.13039/501100000268
Grant:
BB/J018635/1
BB/J018635/1
Publisher:
Wiley
Journal:
Glia More from this journal
Volume:
68
Issue:
2
Pages:
435-450
Place of publication:
United States
Publication date:
2019-10-18
Acceptance date:
2019-09-19
DOI:
EISSN:
1098-1136
ISSN:
0894-1491
Pmid:
31626379
Language:
English
Keywords:
Pubs id:
1063778
Local pid:
pubs:1063778
Deposit date:
2020-04-03

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