Antenatal glucocorticoid exposure and long-term alterations in aortic function and glucose metabolism.

Journal article

OBJECTIVE: Animal studies have demonstrated long-term effects of in utero glucocortcoid exposure on vascular development and glucose metabolism. We hypothesized that there would be a similar impact in humans. METHODS: One hundred and two young adults born preterm aged 23 to 28 years, with prospective data collection from birth, and 95 adults born term after uncomplicated pregnancies underwent cardiovascular MRI. We compared cardiac and aortic structure and function, as well as cardiovascular ...

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Authors: Kelly, B; Lewandowski, A; Worton, SA; Davis, E; Lazdam, M

• Publication status: Published
• Journal: Pediatrics
• Volume: 129
• Issue: 5
• Pages: e1282-e1290
• Publication date: 2012-05-01
• DOI: 10.1542/peds.2011-3175
• EISSN: 1098-4275
• ISSN: 0031-4005
• Language: English
• Keywords: Blood Glucose; Humans; Blood Pressure; Pregnancy; Blood Flow Velocity; Adult; Glucocorticoids; Male; Insulin-Secreting Cells; Case-Control Studies; Vascular Resistance; Young Adult; Aorta, Thoracic; Female; Prenatal Exposure Delayed Effects