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Role of the C-terminal domain of RNA polymerase II in expression of small nuclear RNA genes.

Abstract:

Pol II (RNA polymerase II) transcribes the genes encoding proteins and non-coding snRNAs (small nuclear RNAs). The largest subunit of Pol II contains a distinctive CTD (C-terminal domain) comprising a repetitive heptad amino acid sequence, Tyr(1)-Ser(2)-Pro(3)-Thr(4)-Ser(5)-Pro(6)-Ser(7). This domain is now known to play a major role in the processes of transcription and co-transcriptional RNA processing in expression of both snRNA and protein-coding genes. The heptapeptide repeat unit can be...

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Publication status:
Published

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Publisher copy:
10.1042/bst0360537

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Biochemical Society transactions
Volume:
36
Issue:
Pt 3
Pages:
537-539
Publication date:
2008-06-01
Event title:
Biochemical-Society-Irish-Area-Section Annual Meeting on Ubiquitin and Ubiquitin-Like Modification in Health and Disease
DOI:
EISSN:
1470-8752
ISSN:
0300-5127
Source identifiers:
29949
Keywords:
Pubs id:
pubs:29949
UUID:
uuid:a6983f11-ce2a-44e7-8015-b8af03a805e2
Local pid:
pubs:29949
Deposit date:
2012-12-19

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