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Electrohydrodynamic comminution: a novel technique for the aerosolisation of plasmid DNA.

Abstract:

PURPOSE: Naked plasmid DNA (pDNA) is a potential gene transfer agent for lung gene therapies but cannot be aerosolised without degradation using conventional nebulisation devices. This study investigated the viability of an alternative nebulisation technique, electrohydrodynamic (EHD) comminution for the aerosol delivery of naked DNA in vivo. METHODS: Naked pDNA was aerosolised using jet and ultrasonic nebulisers, and by EHD comminution. Degradation associated with the aerosolisation process...

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Publication status:
Published

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Publisher copy:
10.1007/s11095-005-5268-6

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Journal:
Pharmaceutical research
Volume:
22
Issue:
8
Pages:
1294-1304
Publication date:
2005-08-05
DOI:
EISSN:
1573-904X
ISSN:
0724-8741
URN:
uuid:a6929356-556c-4c21-b890-77da54f8e233
Source identifiers:
246411
Local pid:
pubs:246411

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