- Abstract:
-
PURPOSE: Naked plasmid DNA (pDNA) is a potential gene transfer agent for lung gene therapies but cannot be aerosolised without degradation using conventional nebulisation devices. This study investigated the viability of an alternative nebulisation technique, electrohydrodynamic (EHD) comminution for the aerosol delivery of naked DNA in vivo. METHODS: Naked pDNA was aerosolised using jet and ultrasonic nebulisers, and by EHD comminution. Degradation associated with the aerosolisation process...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1007/s11095-005-5268-6
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- Journal:
- Pharmaceutical research
- Volume:
- 22
- Issue:
- 8
- Pages:
- 1294-1304
- Publication date:
- 2005-08-05
- DOI:
- EISSN:
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1573-904X
- ISSN:
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0724-8741
- URN:
-
uuid:a6929356-556c-4c21-b890-77da54f8e233
- Source identifiers:
-
246411
- Local pid:
- pubs:246411
- Copyright date:
- 2005
Journal article
Electrohydrodynamic comminution: a novel technique for the aerosolisation of plasmid DNA.
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