Journal article
Electrohydrodynamic comminution: a novel technique for the aerosolisation of plasmid DNA.
- Abstract:
-
PURPOSE: Naked plasmid DNA (pDNA) is a potential gene transfer agent for lung gene therapies but cannot be aerosolised without degradation using conventional nebulisation devices. This study investigated the viability of an alternative nebulisation technique, electrohydrodynamic (EHD) comminution for the aerosol delivery of naked DNA in vivo. METHODS: Naked pDNA was aerosolised using jet and ultrasonic nebulisers, and by EHD comminution. Degradation associated with the aerosolisation process...
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- Publication status:
- Published
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- Publisher copy:
- 10.1007/s11095-005-5268-6
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Authors
Bibliographic Details
- Journal:
- Pharmaceutical research
- Volume:
- 22
- Issue:
- 8
- Pages:
- 1294-1304
- Publication date:
- 2005-08-01
- DOI:
- EISSN:
-
1573-904X
- ISSN:
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0724-8741
- Source identifiers:
-
246411
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:246411
- UUID:
-
uuid:a6929356-556c-4c21-b890-77da54f8e233
- Local pid:
- pubs:246411
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2005
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