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The effects of dopamine and adrenaline infusions on acid-base balance and systemic haemodynamics in severe infection.

Abstract:

BACKGROUND: Adrenaline is used increasingly in the management of septic shock, but its efficacy and safety are uncertain. METHODS: In an open, randomised, crossover study we compared the effects of stepped doses of adrenaline 0.1 to 0.5 microgram/kg per min and dopamine 2.5 to 10 micrograms/kg per min on the haemodynamic and acid-base status of 23 patients critically ill with severe sepsis (n = 10) or severe malaria (n = 13). FINDINGS: All patients completed the dopamine study whereas in 16 (...

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Publication status:
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Bethell, DP More by this author
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Journal:
Lancet
Volume:
348
Issue:
9022
Pages:
219-223
Publication date:
1996-07-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:a6921675-3fce-4a56-b56e-6c455fce12b5
Source identifiers:
45213
Local pid:
pubs:45213

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