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Journal article

Discovery of a selective inhibitor for the YEATS domains of ENL/AF9

Abstract:

Eleven-nineteen leukemia (ENL) contains an epigenetic reader domain (YEATS domain) that recognizes lysine acylation on histone 3 and facilitates transcription initiation and elongation through its interactions with the super elongation complex (SEC) and the histone methyl transferase DOT1L. Although it has been known for its role as a fusion protein in mixed lineage leukemia (MLL), overexpression of native ENL, and thus dysregulation of downstream genes in acute myeloid leukemia (AML), has re...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1177/2472555218809904

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Target Discovery Institute
Role:
Author
ORCID:
0000-0003-0560-9416
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Target Discovery Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Target Discovery Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Target Discovery Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Target Discovery Institute
Role:
Author
Expand authors...
Bayer Pharma AG More from this funder
Boehringer Ingelheim More from this funder
Canada Foundation for Innovation More from this funder
Eshelman Institute for Innovation More from this funder
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Publisher:
SAGE Publications Publisher's website
Journal:
Slas Discovery Journal website
Publication date:
2018-10-25
Acceptance date:
2018-10-08
DOI:
EISSN:
2472-5560
ISSN:
2472-5552
Pubs id:
pubs:934899
URN:
uri:a691e5c3-d608-41f0-8808-524d122a93f3
UUID:
uuid:a691e5c3-d608-41f0-8808-524d122a93f3
Local pid:
pubs:934899
Language:
English
Keywords:

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