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Variation in the lipoprotein lipase gene influences exercise-induced left ventricular growth.

Abstract:

The adult heart relies predominantly on fatty acids (FA) for energy generation, and defects in FA catabolism cause dramatic left ventricular (LV) growth in early age. Since lipoprotein lipase (LPL) is the key enzyme in plasma triglyceride catabolism and is highly expressed in the myocardium, we investigated an association between the functional LPL gene serine 447 stop (S447X) variant and exercise-induced LV growth. The S447X variant was genotyped in 146 British Army recruits undergoing a 10-...

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Publication status:
Published

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Publisher copy:
10.1007/s00109-005-0002-8

Authors


Flavell, DM More by this author
Wootton, PT More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine
Pennell, DJ More by this author
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Journal:
Journal of molecular medicine (Berlin, Germany)
Volume:
84
Issue:
2
Pages:
126-131
Publication date:
2006-02-05
DOI:
EISSN:
1432-1440
ISSN:
0946-2716
URN:
uuid:a6895829-050d-4a25-acac-c59960fd6767
Source identifiers:
104822
Local pid:
pubs:104822

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